AMPK 在骨骼肌功能和代谢中的作用

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AMPK in skeletal muscle function and metabolism

Abstract

摘要

Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions. AMPK is a sensor of intracellular energy status that maintains energy stores by fine‐tuning anabolic and catabolic pathways. AMPK’s role as an energy sensor is particularly critical in tissues displaying highly changeable energy turnover. Due to the drastic changes in energy demand that occur between the resting and exercising state, skeletal muscle is one such tissue. Here, we review the complex regulation of AMPK in skeletal muscle and its consequences on metabolism (e.g., substrate uptake, oxidation, and storage as well as mitochondrial function of skeletal muscle fibers). We focus on the role of AMPK in skeletal muscle during exercise and in exercise recovery. We also address adaptations to exercise training, including skeletal muscle plasticity, highlighting novel concepts and future perspectives that need to be investigated. Furthermore, we discuss the possible role of AMPK as a therapeutic target as well as different AMPK activators and their potential for future drug development.— Kjøbsted, R., Hingst, J. R., Fentz, J., Foretz, M., Sanz, M.‐N., Pehmøller, C., Shum, M., Marette, A., Mounier, R., Treebak, J. T., Wojtaszewski, J. F. P., Viollet, B., Lantier, L. AMPK in skeletal muscle function and metabolism. FASEB J. 32, 1741–1777 (2018). www.fasebj.org

骨骼肌具有显著的适应各种生理条件的能力。AMPK 是一种细胞内能量状态的传感器,通过微调合成和分解代谢途径来维持能量储存。AMPK 作为能量传感器的作用在显示高度可变能量周转的组织中尤其重要。由于静息状态和运动状态之间的能量需求发生了剧烈的变化,骨骼肌就是这样一种组织。在这里,我们综述了 AMPK 在骨骼肌中的复杂调节及其对代谢的影响(例如,底物摄取,氧化,储存和骨骼肌纤维的线粒体功能)。我们的重点是 AMPK 在运动过程中骨骼肌和运动恢复中的作用。我们还讨论了适应运动训练,包括骨骼肌可塑性,突出新的概念和未来的前景,需要调查。此外,我们还讨论了 AMPK 作为治疗靶点的可能作用以及不同的 AMPK 激活剂及其未来药物开发的潜力。FASEB j. 32,1741-1777(2018).Www.fasebj. org

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