紫檀芪对健康的益处 + 剂量和副作用

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Pterostilbene Health Benefits + Dosage & Side Effects

Written by 作者:Puya Yazdi, MD 医学博士普亚 · 亚兹迪 | Reviewed by 审核:Ana Aleksic, MSc (Pharmacy) Ana Aleksic,硕士(药学) | Last updated: 最后更新: August 7, 2020 2020年8月7日

Jonathan Ritter

Medically reviewed by 医学评论:Jonathan Ritter, PharmD, PhD (Pharmacology) 乔纳森 · 里特医学博士(药理学)

Blueberries

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They say it’s better than resveratrol. They call it dragon’s blood, or even the fountain of youth. Does science back up the hype? What are the limitations and risks? Find out here.

他们说这比白藜芦醇好。他们称之为龙血,甚至青春之泉。科学支持这种炒作吗?限制和风险是什么?你可在此查阅详情。

What is Pterostilbene? 什么是紫檀?

Pterostilbene is an antioxidant found in many plants, including almonds, grape leaves and vines,blueberries and related Vaccinium berries, peanuts, dracaena plants, and Indian kino. Blueberries are the richest dietary source of pterostilbene; some trees produce it in “dragon’s blood,” a red resin with a long history of traditional use [1, 2, 3, 4, 5, 6, 7].

紫檀是一种抗氧化剂,存在于许多植物中,包括杏仁、葡萄叶和葡萄藤、蓝莓和相关的越橘浆果、花生、龙血树植物和印度金针树。蓝莓是紫檀木最丰富的食物来源; 一些树木用“龙血”产生它,龙血是一种红色树脂,有着悠久的传统使用历史[1,2,3,4,5,6,7]。

Trans-pterostilbene 反式紫檀烯

Some supplements are labeled with “trans-pterostilbene” rather than just “pterostilbene.” This compound actually has many names, one of which is trans-3,5-dimethoxy-4′-hydroxystilbene [8].

有些补充剂的标签是“反式 -pterostilbene”而不是“ pterostilbene”该化合物实际上有许多名称,其中之一是反式3,5- 二甲氧基 -4′-羟基二苯乙烯[8]。

In chemistry, the word “trans” tells us that certain atoms (or groups of atoms) are on opposite sides of a molecule’s physical structure. The word “cis” tells us that those atoms are on the same side of the molecule. Both trans-pterostilbene and cis-pterostilbene are found in nature, though the trans form is more stable [8, 9, 10].

在化学中,“反式”这个词告诉我们,某些原子(或原子群)在分子物理结构的两侧。“顺式”这个词告诉我们,这些原子在分子的同一侧。反式-紫檀二苯乙烯和顺式-紫檀二苯乙烯都存在于自然界,尽管反式形式更稳定[8,9,10]。

The word pterostilbene alone, without a modifier, refers to the trans form by default. The cis form will always be called cis-pterostilbene [11, 12].

单词 pterostilbene,没有修饰语,在缺省情况下指的是反式。顺式形式将始终被称为顺 -pterostilbene [11,12]。

Pterostilbene vs. Resveratrol 紫檀芪和白藜芦醇

Pterostilbene is part of a class of compounds called phytoalexins: in plants, these compounds defend against microbes and parasites. It is very similar to a better-known phytoalexin antioxidant, resveratrol. However, pterostilbene is about four times easier to absorb from the gut into the body; in theory, that could make it multiple times more effective than resveratrol, but this has yet to be confirmed in any formal study [131415].

紫檀属于植物抗毒素类化合物的一部分: 在植物中,这些化合物能抵御微生物和寄生虫。它与众所周知的植物抗毒素抗氧化剂白藜芦醇非常相似。然而,紫檀二苯乙烯比从肠道吸收容易四倍; 理论上,这可以使它比白藜芦醇有效多倍,但这还没有在任何正式研究中得到证实[13,14,15]。

Proponents:

支持者:

  • May support weight loss 可以帮助减肥
  • May improve cognition 可以提高认知能力
  • May help control blood sugar & blood pressure 有助于控制血糖和血压
  • Antioxidant benefits to liver, heart, and eyes 对肝脏、心脏和眼睛有抗氧化作用
  • More bioavailable than resveratrol 比白藜芦醇有更多的生物利用性

Skeptics:

怀疑论者:

  • May increase LDL cholesterol 可能增加低密度脂蛋白胆固醇
  • Drug interactions possible 可能的药物相互作用
  • Very limited human research 非常有限的人类研究
  • Significant risk of bias in clinical studies 临床研究中的重大偏倚风险

Potential Benefits with Insufficient Evidence 证据不足的潜在好处

Pterostilbene has produced positive results for weight loss in at least one study, but larger and more robust studies are required to confirm its effectiveness.

至少在一项研究中,紫檀已经在减肥方面产生了积极的结果,但还需要更大规模、更强有力的研究来证实其有效性。

Furthermore, the FDA has not approved pterostilbene for any medical purpose or health claim, and there is no guarantee of the quality of any given supplement. Talk to your doctor before supplementing with pterostilbene.

此外,FDA 还没有批准 pterostilbene 用于任何医疗用途或健康声明,也没有任何特定补充剂的质量保证。补充紫檀前请咨询你的医生。

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