吡咯并喹啉醌(PQQ)概要,主要信息,健康益处,副作用,使用和其他重要细节

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Summary of Pyrroloquinoline quinone

Primary information, health benefits, side effects, usage, and other important details

主要信息,健康益处,副作用,使用和其他重要细节

Pyrroloquinoline quinone (henceforth PQQ) is a small quinone molecule which has the ability to be a REDOX agent, capable of reducing oxidants (an antioxidant effect) and then being recycled by glutathione back into an active form. It appears to be quite stable as it can undergo several thousand cycles before being used up, and it is novel since it associates with protein structures inside the cell (some antioxidants, mostly notably carotenoids like β-carotene and astaxanthin, are located at specific areas of a cell where they exert proportionally more antioxidant effects due to proximity; PQQ seems to do this near proteins like carotenoids do so at the cell membrane).

吡咯并喹啉醌是一种小的醌类分子,可以作为氧化还原剂,能够还原氧化剂(一种抗氧化剂) ,然后通过谷胱甘肽回收成活性形式。它似乎相当稳定,因为它可以经过几千个循环才被用完,而且它是新颖的,因为它与细胞内的蛋白质结构有关(一些抗氧化剂,主要是类胡萝卜素,如-胡萝卜素和虾青素,位于细胞的特定区域,由于它们靠近细胞,在这些区域发挥更大的抗氧化作用; PQQ 似乎在类胡萝卜素这样的蛋白质附近发挥抗氧化作用,在细胞膜上也是如此)。

The aforementioned REDOX functions can alter protein function and signalling pathways, and while there is a lot of promising in vitro (outside of a living model) research on what it could do there are only a few promising results of PQQ supplementation, mostly related to either altering some signalling pathways or via its benefits to mitochondria (producing more of them and increasing their efficiency).

上述的氧化还原功能可以改变蛋白质功能和信号通路,虽然有许多有希望的体外研究(生物模型之外) ,它可以做什么,只有一些有希望的结果 PQQ 补充,主要涉及改变一些信号通路或通过其对线粒体的好处(生产更多的这些和提高其效率)。

It is a coenzyme in bacteria (so, to bacteria, this would be something like a B-vitamin) but this role does not appear to extend to humans. Since this does not extend to humans, the designation of PQQ as a vitamin compound has fallen through and it is only considered ‘vitamin-like’ at best.

它是细菌中的一种辅酶(所以,对细菌来说,它可能类似于 b 族维生素) ,但是这种作用似乎不适用于人类。由于这并不适用于人类,PQQ 作为一种维生素化合物的指定已经失败,它充其量只被认为是“类维生素”。

PQQ seems to modify oxidation in a cell after binding to some proteins, and this modulatory role it plays can alter the signalling processes that go on in a cell. Due to PQQ being a REDOX agent (capable of both reducing and oxidizing) it is not a pure antioxidant, but it is involved in a cyclical antioxidative cycle with an antioxidant enzyme known as glutathione PQQ 似乎在与某些蛋白质结合后改变了细胞中的氧化,这种调节作用可以改变细胞中正在进行的信号传导过程。由于 PQQ 是一种氧化还原剂(能够还原和氧化) ,它不是一种纯抗氧化剂,但它与抗氧化酶谷胱甘肽有一个循环的抗氧化循环

For human evidence, the limited evidence we have right now suggests a possible neuroprotective role in the aged (no research in clinical situations of neurodegeneration nor in youth) and it may have an antiinflammatory role. This limited evidence also suggests that the main claim of PQQ, an enhancement of mitochondrial function, occurs in otherwise healthy humans given PQQ supplementation.

对于人类的证据,我们现有的有限证据表明,它可能在老年人中起到神经保护作用(没有关于神经退行性疾病的临床研究,也没有关于年轻人的研究) ,而且它可能具有抗炎作用。这个有限的证据也表明,PQQ 的主要功能,线粒体功能的增强,发生在给予 PQQ 补充剂的其他健康人身上。

The animal evidence that might apply to humans (using oral supplementation at doses similar to what humans use) include a radioprotective effect, possible benefits to insulin resistance, and being a growth factor when PQQ is added to the diet over a long period of time. Higher than normal oral doses in rodents seem to also enhance peripheral neurogenesis (nerve growth outside of the brain) but not necessarily in the brain.

可能适用于人类的动物证据(使用与人类使用剂量相似的口服补充剂)包括放射防护作用、对胰岛素抵抗可能的益处,以及当长期将 PQQ 添加到饮食中时成为一种生长因子。高于正常口服剂量的啮齿类动物似乎也加强了外周神经发生(神经生长以外的大脑) ,但不一定在大脑。

A large amount of the evidence for a direct antioxidant role or the neurological actions related to NMDA signalling of PQQ seem to use very high concentrations in cells, due to possible transportation issues to the brain and low concentrations of PQQ found in the blood following oral ingestion.

大量的证据表明 PQQ 具有直接的抗氧化作用或者与 NMDA 信号相关的神经系统活动,这些证据似乎在细胞中使用了非常高的浓度,这是由于可能的向大脑的运输问题和口服后血液中发现的低浓度的 PQQ。

It holds a potential to modify signalling in humans, and although the oxidation in the blood (easiest thing to measure) in mostly unaffected it also retains the potential to act as an intracellular antioxidant. The enhancement of mitochondrial function may also occur, but beyond some alterations in signalling and the mitochondrial biogenesis most other properties of PQQ are unlikely to extend to humans 它具有改变人体信号传递的潜力,虽然血液中的氧化作用(最容易测量)基本上不受影响,但它也保留了作为细胞内抗氧化剂的潜力。线粒体功能的增强也可能发生,但除了信号通路和线粒体生物发生的某些改变之外,PQQ 的大多数其他特性不大可能延伸到人类

 Make sure you only take supplements that work

确保你只服用有效的补充剂

If you’re tired of wasting time and money on supplements that don’t work, our 17 Supplement Guides will help you figure out precisely what to take — and what to skip — based on your health goals and the latest scientific evidence. There’s a reason why over 50,000 customers rely on Examine.com’s independent and unbiased analysis.

如果你厌倦了把时间和金钱浪费在无效的补充剂上,我们的17条补充指南将根据你的健康目标和最新的科学证据,帮助你精确地找出该吃什么,该跳过什么。这就是为什么超过50,000的消费者依赖于 audit.com 的独立和公正的分析。
I want unbiased recommendations to improve my health » 我希望得到公正的建议,以改善我的健康状况”

 How to Take

如何接受

Medical Disclaimer 医学上的免责声明

Recommended dosage, active amounts, other details

推荐剂量,活性剂量,其他细节

The optimal dosage of Pyrroloquinoline quinone (PQQ) to be taken daily is currently not known, but extrapolations from animal studies suggest that doses as low as 2mg are somewhat bioactive while most dietary supplements are sold in the 20-40mg range.

吡咯并喹啉醌的最佳剂量目前尚不清楚,但动物研究的推断表明,低至2毫克的剂量有些生物活性,而大多数膳食补充剂的销售量在20-40毫克之间。

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通过成为研究会员,了解400多种补充剂的最新研究及其对600多种健康结果的影响。

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 Human Effect Matrix

人类效应矩阵

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The Human Effect Matrix summarizes human studies to tell you what effects Pyrroloquinoline quinone has on your body, how much evidence there is, and how strong these effects are.

人类效应矩阵总结了人类研究,告诉你吡咯并喹啉醌对你的身体有什么影响,有多少证据,以及这些影响有多么强烈。Full details are available to 有关详情,请浏览

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GRADE职系LEVEL OF EVIDENCE 证据水平[show legend] [表演传奇]
LEVEL OF EVIDENCE 证据水平?OUTCOME 结果MAGNITUDE OF EFFECT 影响的幅度?CONSISTENCY OF RESEARCH RESULTS研究结果的一致性?NOTES 注释
grade-dC-Reactive Protein C反应蛋白Notable 值得注意See study 参见研究The decrease in C-reactive protein seen in one study in otherwise healthy humans reached 45% after three weeks of supplementation. 在一项研究中发现,在其他健康人群中,补充三周后,C反应蛋白的下降幅度达到45%
grade-dFatigue 疲劳Minor 未成年人See study 参见研究A decrease in fatigue has been noted in older adults with self-reported energy problems 有自我报告的能量问题的老年人的疲劳程度有所下降
grade-dInterleukin 6 白细胞介素6Minor 未成年人See study 参见研究IL-6 appeared to be significantly reduced in the serum of adults given PQQ supplementation relative to baseline. 相对于基线水平,服用 PQQ 补充剂的成年人血清中 IL-6显著降低
grade-dLipid Peroxidation 脂质过氧化Minor 未成年人See study 参见研究Although a decrease technically exists as assessed by TBARS, the decrease was measured at around 0.2% and is practically irrelevant. 虽然技术上存在着 TBARS 评估的下降,但是这种下降被测量在0.2% 左右,实际上是无关的
grade-dPain 痛苦Minor 未成年人See study 参见研究In persons with sleep disorders taking PQQ (which improved sleep) there were reductions in pain ratings at the end of the trial 在服用 PQQ (一种改善睡眠的药物)的睡眠障碍患者中,在试验结束时疼痛评分有所下降
grade-dSleep Quality睡眠质量Minor 未成年人See study 参见研究An improvement in sleep quality has been noted in persons with impaired sleep; it is not certain how PQQ affects persons with normal sleep cycles 睡眠受损者的睡眠质量有所改善,但 PQQ 如何影响睡眠周期正常的人尚不清楚
grade-dStress 压力Minor 未成年人See study 参见研究A reduction in self-reported stress has been noted after 8 weeks in persons with self-reported sleep problems; this study also noted improvements in sleep 自我报告有睡眠问题的人在8周后自我报告的压力有所减少,这项研究也注意到睡眠方面的改善
grade-dTMAO 氧化三甲胺Minor 未成年人See study 参见研究A decrease in urinary TMAO has been noted with supplementation of PQQ, which is thought to be due to increased activity of the FMO3 enzyme. 补充 PQQ 后,尿中 TMAO 下降,这被认为是由于 FMO3酶的活性增加
grade-dBlood Glucose血糖See study 参见研究Short term ingestion of PQQ supplementation in otherwise healthy adults has failed to significantly influence serum glucose concentrations. 短期服用 PQQ 补充剂对其他健康成年人的血糖浓度没有显著影响
grade-dGeneral Oxidation 一般氧化作用See study 参见研究Overall oxidation in serum as assessed by TRAP has failed to be significantly influenced by PQQ supplementation in otherwise healthy adults. 在其他健康成年人中,TRAP 评估的血清总体氧化未能受到 PQQ 补充剂的显著影响
grade-dHDL-C 高密度脂蛋白 cSee study 参见研究Three weeks supplementation of PQQ has failed to significantly influence HDL cholesterol levels in otherwise healthy adults. 补充三周的 PQQ 对其他健康成年人的 HDL 胆固醇水平没有显著影响
grade-dLDL-C 低密度脂蛋白 cSee study 参见研究No apparent changes to LDL cholesterol exist in otherwise healthy adults given PQQ supplementation daily for up to three weeks. 在其他健康成年人中,每天服用 PQQ 补充剂长达三周时,LDL 胆固醇水平没有明显变化
grade-dLiver Enzymes肝酶See study 参见研究Serum ALT is not affected by supplementation of PQQ for up to three weeks. 补充 PQQ 长达三周时间对血清 ALT 无影响
grade-dTriglycerides 甘油三酯See study 参见研究Short term supplementation of PQQ has failed to significantly influence triglycerides in otherwise healthy adults 短期补充 PQQ 对其他健康成年人的甘油三酯没有显著影响

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