Multivitamin, mineral supplement linked to less-severe, shorter-lasting illness symptoms

Date: 日期:August 18, 2020 2020年8月18日Source: 来源:Oregon State University 俄勒冈州立大学Summary: 摘要:Older adults who took a daily multivitamin and mineral supplement with zinc and high amounts of vitamin C in a 12-week study experienced sickness for shorter periods and with less severe symptoms than counterparts in a control group receiving a placebo. 在一项为期12周的研究中,老年人每天服用多种维生素和矿物质补充剂、锌和高剂量维生素 c,与服用安慰剂的对照组相比,他们患病的时间较短,症状也较轻

Older adults who took a daily multivitamin and mineral supplement with zinc and high amounts of vitamin C in a 12-week study experienced sickness for shorter periods and with less severe symptoms than counterparts in a control group receiving a placebo.

在一项为期12周的研究中,老年人每天服用多种维生素和矿物质补充剂、锌和高剂量维生素 c,与服用安慰剂的对照组相比,他们患病的时间较短,症状也较轻。

The findings by Oregon State University researchers were published in the journal Nutrients.


The research by scientists at OSU’s Linus Pauling Institute involved 42 healthy people ages 55 to 75 and was designed to measure the supplement’s effects on certain immune system indicators. It also looked at bloodstream levels of zinc and vitamins C and D while taking the supplement, as these micronutrients are important for proper immune function.

俄勒冈州立大学莱纳斯 · 鲍林研究所的科学家们对42名年龄在55岁到75岁之间的健康人进行了这项研究,旨在测量补充剂对某些免疫系统指标的影响。研究还观察了补充维生素 c 和 d 时血液中锌和维生素 c 和 d 的含量,因为这些微量营养素对于正常的免疫功能很重要。

The immune indicators, including white blood cells’ ability to kill incoming pathogens, were unaltered in the group receiving the supplement.


The multivitamin group showedimproved vitamin C and zinc status in the blood. Most intriguingly, illness symptoms reported by this group were less severe and went away faster than those experienced by the placebo group.

复合维生素组证实了血液中维生素 c 和锌的含量。最有趣的是,与安慰剂组相比,这组患者报告的疾病症状没有那么严重,而且消失得更快。

The same percentage of participants in each group reported symptoms, but days of sickness in the supplement group averaged fewer than three compared to more than six for the placebo group.


“The observed illness differences were striking,” said corresponding author Adrian Gombart, professor of biochemistry and biophysics in the OSU College of Science and a principal investigator at the Linus Pauling Institute. “While the study was limited to self-reported illness data and we did not design the study to answer this question, the observed differences suggest that additional larger studies designed for these outcomes are warranted — and, frankly, overdue.”

通讯作者 Adrian gobart 说,他是俄勒冈州立大学理学院的生物化学和生物物理学教授,也是学术带头人的莱纳斯 · 鲍林研究所的一名研究员。“虽然这项研究仅限于自我报告的疾病数据,我们并没有设计这项研究来回答这个问题,但观察到的差异表明,针对这些结果设计的更大规模的研究是有道理的——而且坦白地说,早该如此。”

As people get older, the risk of vitamin and mineral deficiencies that contribute to age-related immune system deficiencies rises. Across the United States, Canada and Europe, research suggests more than one-third of older adults are deficient in at least one micronutrient, often more than one.


“That likely contributes to a decline in the immune system, most often characterized by increased levels of inflammation, reduced innate immune function and reduced T-cell function,” Gombart said. “Since multiple nutrients support immune function, older adults often benefit from multivitamin and mineral supplements. These are readily available, inexpensive and generally regarded as safe.”

贡巴特说: “这可能导致免疫系统的衰退,最常见的拥有属性是增加炎症水平,降低先天免疫功能和减少 t 细胞功能。”。“由于多种营养素支持免疫功能,老年人常常受益于多种维生素和矿物质补充剂。这些产品容易买到,价格低廉,而且通常被认为是安全的。”

The multivitamin supplement used in the study focused on vitamins and minerals typically thought to help immunity. It contained 700 micrograms of vitamin A; 400 international units of vitamin D; 45 milligrams of vitamin E; 6.6 milligrams of vitamin B6; 400 micrograms of folate; 9.6 micrograms of vitamin B12; 1,000 milligrams of vitamin C; 5 milligrams of iron; 0.9 milligrams of copper; 10 milligrams of zinc; and 110 micrograms of selenium.

这项研究中使用的复合维生素补充剂主要是维生素和矿物质,通常被认为有助于免疫力。它含有700微克的维生素 a; 400国际单位的维生素 d; 45毫克的维生素 e; 6.6毫克的维生素 B6; 400微克的叶酸; 9.6微克的维生素 B12; 1000毫克的维生素 c; 5毫克的铁; 0.9毫克的铜; 10毫克的锌; 和110微克的硒。

“Supplementation was associated with significantly increased circulating levels of zinc and vitamin C, and with illness symptoms that were less severe and shorter lasting,” Gombart said. “This supports findings that stretch back decades, even to the days of Linus Pauling’s work with vitamin C. Our results suggest more and better designed research studies are needed to explore the positive role multivitamin and mineral supplementation might play in bolstering the immune system of older adults.”

贡巴特说: “补充锌与循环系统中锌和维生素 c 的水平显著增加有关,与疾病症状不那么严重、持续时间较短有关。”。“这支持了几十年前的发现,甚至可以追溯到莱纳斯 · 鲍林研究维生素 c 的时代。我们的研究结果表明,需要更多更好设计的研究来探索多种维生素和矿物质补充剂在增强老年人免疫系统方面可能发挥的积极作用。”


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