科学家发现了使人类棕色脂肪燃烧能量的开关

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Scientists discover the switch that makes human brown fat burn energy

Date: 日期:August 5, 2020 2020年8月5日Source: 来源:University of Copenhagen The Faculty of Health and Medical Sciences 哥本哈根大学健康与医学系Summary: 摘要:The receptor responsible for activating the energy-burning property of brown fat in humans has been identified. The next step is to investigate drugs that fit the receptor and trigger the response as a means to treat obesity and type-2 diabetes. 人体内负责激活棕色脂肪能量燃烧特性的受体已经被确认。下一步是研究适合该受体的药物,并将其作为治疗肥胖和2型糖尿病的手段Share: 分享:    FULL STORY 完整故事


An international research team have discovered how to activate brown fat in humans, which may lead to new treatments for type 2 diabetes and obesity. The results of the collaboration between the Centre de recherche du Centre hospitalier universitaire de Sherbrooke (CRCHUS) and the Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR) at the University of Copenhagen were published today in Cell Metabolism.

一个国际研究小组已经发现了如何激活人体内的棕色脂肪,这可能导致治疗2型糖尿病和肥胖症的新方法。舍布鲁克大学中心医院研究中心(CRCHUS)和哥本哈根大学诺和诺德基金会基础代谢研究中心(CBMR)的合作成果今天发表在《细胞代谢》杂志上。

Brown fat burns energy and generates heat — a process called thermogenesis — after being activated by cold temperature or chemical signals. Humans have small deposits of brown fat, and scientists have long hypothesized that finding alternative ways to pharmacologically activate the fat could help improve metabolism.

棕色脂肪在被低温或化学信号激活后,燃烧能量并产生热量,这个过程被称为热生成。人体内有少量的棕色脂肪沉积,长期以来,科学家们一直假设寻找其他药物活化棕色脂肪的方法可以帮助改善新陈代谢。

Scientists have now discovered that beta2-adrenergic receptors (b2-AR) in brown fat cells are responsible for stimulating thermogenesis. According to Dr. Denis Blondin from CRCHUS, the finding could explain why most clinical trials, which have attempted to induce BAT to burn energy, have performed poorly.

科学家们现在发现,棕色脂肪细胞中的 beta2肾上腺素能受体(b2-AR)负责刺激产热。来自 CRCHUS 的 Denis Blondin 博士认为,这一发现可以解释为什么大多数试图诱导 BAT 燃烧能量的临床试验表现不佳。

“We show that perhaps we were aiming for the wrong target all along. In contrast to rodents, human BAT is activated through the stimulation of the beta2-adrenergic receptor, the same receptor responsible for the release of fat from our white adipose tissue.”

“我们表明,或许我们一直瞄准的目标是错误的。与啮齿类动物相反,人类的 BAT 是通过刺激 beta2-肾上腺素能受体激活的,这种受体与我们的白色脂肪组织释放脂肪的受体相同。”

Unlocking the therapeutic potential of brown fat

释放棕色脂肪的治疗潜力

According to Associate Professor Camilla Schéele at CBMR, this finding has clear therapeutic applications. “Activation of brown fat burns calories, improves insulin sensitivity and even affects appetite regulation. Our data reveals a previously unknown key to unlocking these functions in humans, which would potentially be of great gain for people living with obesity or type 2 diabetes.”

根据 CBMR 副教授 Camilla Schéele 的说法,这一发现有明确的治疗应用。“棕色脂肪的激活可以燃烧卡路里,提高胰岛素敏感性,甚至影响食欲调节。我们的数据揭示了一个先前未知的解开人类这些功能的关键,这可能对肥胖或2型糖尿病患者有很大的好处。”

A second phase of research will begin in the autumn, which will attempt to validate the finding by activating brown fat with drugs that target b2-AR, explains Professor André Carpentier from CRCHUS:

第二阶段的研究将在秋天开始,它将尝试通过靶向 b2-AR 的药物激活棕色脂肪来验证这一发现,CRCHUS 的安德烈 · 卡彭蒂埃教授解释说:

“Our next step will be to use a drug that specifically activate that target on brown fat and determine how much it could be of use to burn fat and calories in humans. Once this is done, studies in patients with type 2 diabetes will start to determine if this approach can be useful to improve the metabolic control of the disease.”

“我们的下一步将是使用一种特定激活棕色脂肪靶点的药物,并确定它在多大程度上可用于燃烧人体脂肪和卡路里。一旦做到这一点,对2型糖尿病患者的研究将开始确定这种方法是否有助于改善该疾病的代谢控制。”


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