Lipoic acid supplements help some obese but otherwise healthy people lose weight


Date: 日期:August 12, 2020 2020年8月12日Source: 来源:Oregon State University 俄勒冈州立大学Summary: 摘要:A compound given as a dietary supplement to overweight but otherwise healthy people in a clinical trial caused many of the patients to slim down. 在一项临床试验中,给超重但其他方面健康的人服用一种名为膳食补充剂的化合物,导致许多病人变瘦Share: 分享:    FULL STORY 完整故事

A compound given as a dietary supplement to overweight but otherwise healthy people in a clinical trial caused many of the patients to slim down, research by Oregon State University and Oregon Health & Science University showed.


The research, published in the Journal of Nutrition, analyzed the effects of 24 weeks of daily, 600-milligram doses of lipoic acid supplements on 31 people, with a similarly sized control group receiving a placebo.


“The data clearly showed a loss in body weight and body fat in people taking lipoic acid supplements,” said Balz Frei, director emeritus of OSU’s Linus Pauling Institute and one of the scientists on the study. “Particularly in women and in the heaviest participants.”

“数据清楚地显示,服用硫辛酸补充剂的人体重和脂肪都有所减少,”该研究的科学家之一、俄勒冈州立大学莱纳斯 · 鲍林研究所(Linus Pauling Institute)名誉主任巴尔兹 · 弗雷(Balz Frei)说。“特别是女性和体重最重的运动员。”

Produced by both plants and animals, lipoic acid sets up shop in cells’ mitochondria, where it’s normally attached to proteins involved in energy and amino acid metabolism. A specialized, medium-chain fatty acid, it’s unique in having two sulfur atoms at one end of the chain, allowing for the transfer of electrons from other sources.


The body generally produces enough lipoic acid to supply the enzymes whose proper function requires it. When taken as a dietary supplement, lipoic acid displays additional properties that might be unrelated to the function in the mitochondria. They include the stimulation of glucose metabolism, antioxidant defenses and anti-inflammatory responses — making it a possible complementary treatment for people with diabetes, heart disease and age-related cognitive decline.


“Scientists have been researching the potential health benefits of lipoic acid supplements for decades, including how it might enhance healthy aging and mitigate cardiovascular disease,” said Alexander Michels, another Linus Pauling Institute scientist involved with the study. “In both rodent models and small-scale human clinical trials, researchers at the LPI have demonstrated the beneficial effects of lipoic acid on oxidative stress, lipid metabolism and circadian rhythm.”

“几十年来,科学家们一直在研究硫辛酸补充剂对健康的潜在益处,包括它如何促进健康老龄化和减轻心血管疾病,”参与这项研究的另一位科学家亚历山大 · 米歇尔斯(Alexander Michels)说。“在啮齿动物模型和小规模的人体临床试验中,LPI 的研究人员已经证明了硫辛酸对氧化应激、脂质代谢和昼夜节律的有益作用。”

The OSU/OHSU project addressed two issues commonly ignored by previous human trials, said Tory Hagen, a professor of biochemistry and biophysics in the OSU College of Science and the study’s corresponding author.

俄勒冈州立大学科学学院生物化学和生物物理学教授、该研究的通讯作者托里 · 哈根说,俄勒冈州立大学/奥斯陆大学的项目解决了以前的人体试验普遍忽视的两个问题。

“Many existing clinical studies using lipoic acid have focused on volunteers with pre-existing conditions like diabetes, making it difficult to determine if lipoic acid supplements simply act as a disease treatment or have other beneficial health effects,” said Hagen, principal investigator and Helen P. Rumbel Professor for Healthy Aging Research at the institute. “Another issue is the formulation of the supplement. Many previous studies have used the S form of lipoic acid, which is a product of industrial synthesis and not found in nature. We only used the R form of lipoic acid — the form found in the body naturally.”

该研究所健康老龄化研究学术带头人教授 Hagen 和 Helen p. Rumbel 说: “许多现有的使用硫辛酸的临床研究都集中在那些已经存在糖尿病等疾病的志愿者身上,因此很难确定硫辛酸补充剂是否仅仅起到了治疗疾病的作用,还是具有其他有益的健康效果。”。“另一个问题是补充剂的制定。硫辛酸是一种工业合成的产物,自然界中没有发现。我们只使用了硫辛酸的 r 形式——这种形式是人体自然形成的。”

Contrary to what was expected by the researchers, decreased levels of triglycerides — a type of fat, or lipid, found in the blood — were not seen in all the participants taking lipoic acid.


“The effect of lipoic acid supplements on blood lipids was limited,” said Gerd Bobe, another LPI scientist who collaborated on the study. “But people who lost weight on lipoic acid also reduced their blood triglyceride levels — that effect was clear.”

“硫辛酸补充剂对血脂的影响是有限的,”另一位参与这项研究的 LPI 科学家 Gerd Bobe 说。“但是服用硫辛酸减肥的人也会降低他们的血液甘油三酯水平——这一效果是明显的。”

Other effects of the lipoic acid supplements were measurable as well.


“By the end of the study, some markers of inflammation declined,” Hagen said. “The findings also suggest that lipoic acid supplementation provides a mild reduction in oxidative stress. It is not a perfect panacea, but our results show that lipoic acid supplements can be beneficial.”

“到研究结束时,一些炎症标志物下降了,” Hagen 说。“研究结果还表明,补充硫辛酸可以轻微降低氧化应激。它不是一个完美的灵丹妙药,但我们的研究结果表明,硫辛酸补充剂是有益的。”

Identifying which patients will benefit the most from lipoic acid supplementation, and how much they need, is important for both clinical and economic reasons, he added.


“Lipoic acid supplements are often quite expensive,” he said. “So understanding how we can maximize benefits with smaller amounts of the supplement is something we are interested in pursuing.”



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