膳食吡咯并喹啉醌(PQQ)改变了人体炎症和线粒体相关代谢的指标

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Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects

膳食吡咯并喹啉醌(PQQ)改变了人体炎症和线粒体相关代谢的指标

Calliandra B Harris 1Winyoo ChowanadisaiDarya O Mishchuk 达里亚 · 奥 · 米什丘克Mike A Satre迈克 · a · 萨特Carolyn M Slupsky 卡洛琳 · m · 斯卢普斯基Robert B Rucker 罗伯特 · b · 拉克Affiliations 从属关系expand 扩展

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Abstract

摘要

Pyrroloquinoline quinone (PQQ) influences energy-related metabolism and neurologic functions in animals. The mechanism of action involves interactions with cell signaling pathways and mitochondrial function. However, little is known about the response to PQQ in humans. Using a crossover study design, 10 subjects (5 females, 5 males) ingested PQQ added to a fruit-flavored drink in two separate studies. In study 1, PQQ was given in a single dose (0.2 mg PQQ/kg). Multiple measurements of plasma and urine PQQ levels and changes in antioxidant potential [based on total peroxyl radical-trapping potential and thiobarbituric acid reactive product (TBAR) assays] were made throughout the period of 48 h. In study 2, PQQ was administered as a daily dose (0.3 mg PQQ/kg). After 76 h, measurements included indices of inflammation [plasma C-reactive protein, interleukin (IL)-6 levels], standard clinical indices (e.g., cholesterol, glucose, high-density lipoprotein, low-density lipoprotein, triglycerides, etc.) and (1)H-nuclear magnetic resonance estimates of urinary metabolites related in part to oxidative metabolism. The standard clinical indices were normal and not altered by PQQ supplementation. However, dietary PQQ exposure (Study 1) resulted in apparent changes in antioxidant potential based on malonaldehyde-related TBAR assessments. In Study 2, PQQ supplementation resulted in significant decreases in the levels of plasma C-reactive protein, IL-6 and urinary methylated amines such as trimethylamine N-oxide, and changes in urinary metabolites consistent with enhanced mitochondria-related functions. The data are among the first to link systemic effects of PQQ in animals to corresponding effects in humans.

吡咯并喹啉醌影响动物的能量代谢和神经功能。作用机制涉及与细胞信号通路和线粒体功能的相互作用。然而,人类对 PQQ 的反应却知之甚少。采用交叉研究设计,10个研究对象(5个女性,5个男性)在两个独立的研究中摄入 PQQ 加入水果味饮料。在研究1中,PQQ 单次给药(0.2 mg PQQ/kg)。在整个48小时内,我们多次测量了血浆和尿液中 PQQ 水平以及抗氧化能力的变化[根据总过氧化物自由基捕捉能力和硫代巴比妥酸反应产物(TBAR)测定]。在研究2中,PQQ 以每日0.3毫克 PQQ/千克的剂量给药。76小时后,测量包括炎症指数[血浆 C反应蛋白,白细胞介素(IL)-6水平] ,标准临床指数(如,胆固醇,葡萄糖,高密度脂蛋白,低密度脂蛋白,甘油三酯等)和(1) h 核磁共振估计尿液中与唿吸作用有关的代谢物。标准临床指标正常,PQQ 补充剂未改变。然而,根据与丙二醛相关的 TBAR 评估,饮食中暴露于 PQQ (研究1)会导致抗氧化潜能的明显变化。在研究2中,补充 PQQ 导致血浆中 C反应蛋白、白细胞介素6和尿液中的甲基化胺水平显著下降,尿液中的代谢物变化与增强的线粒体相关功能一致。这些数据是首批将 PQQ 对动物的系统性影响与人类的相应影响联系起来的数据之一。

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