甜菜碱(TMG)-甲基化,抗炎和强大的运动补充

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Betaine (TMG) – Methylation, Anti-Inflammatory and Powerful Exercise Supplement

WRITTEN BY ROB ON MARCH 22, 2017. POSTED IN HEALTH NEWSLEAVE A COMMENT

作者: ROB 2017年3月22日,发布于健康新闻,请留言

Betaine, also known by the name Trimethylglycine (TMG) is well known and utilized within the Practitioner community for its important and profound effects on methylation and Homocysteine levels.

甜菜碱,也被称为甜菜碱,因其对甲基化和同型半胱氨酸水平的重要和深远的影响而在医疗界广为人知。

It is also known for its impact on mood and depression due to the fact when TMG helps to break down Homocysteine into Methionine, and a byproduct of this conversion is SAMe –  S-adenosylmethionine, which is known to be effective in the treatment of depression, schizophrenia, demyelination diseases, liver disease, dementia, arthritis, and other conditions.

由于 TMG 有助于将同型半胱氨酸分解为蛋氨酸,它对情绪和抑郁症的影响也是众所周知的,这种转化的副产品是同型半胱氨酸,这是众所周知的有效治疗抑郁症,精神分裂症,脱髓鞘疾病,肝脏疾病,痴呆症,关节炎和其他条件的 S-腺苷甲硫氨酸。

Recently, the Journal of Neurochemistry reported the brain levels of SAMe in Alzheimer’s patients are severely decreased.

最近,《神经化学杂志》报道,老年痴呆症患者的大脑中同样的水平严重下降。

Perhaps not as well-known is TMG’s significant impact on inflammation, which has significant potential anti-aging effects.
Following is an article from Life-Enhancement Magazine which documents this anti-inflammatory modulation.

也许不是众所周知的是 TMG 的重大影响,炎症,这有显着的潜在抗衰老作用。以下是《生活增强》杂志的一篇文章,它记录了这种消炎调节。

Also we have included an article written by Nicholas Rupcich, PhD (McMaster – Biological Chemistry).

我们还收录了 Nicholas Rupcich 博士的一篇文章(McMaster-Biological Chemistry)。

But first let’s review some of the more well-known potential benefits of TMG supplementation:

但首先让我们回顾一下 TMG 补充剂的一些众所周知的潜在益处:

From Dr. Wilson’s article on TMG:

摘自 Wilson 博士关于 TMG 的文章:

FUNCTIONS OF TMG

TMG 的功能

A powerful and safe methyl donor.  TMG easily donates three methyl groups to the body.  Methyl groups (CH3) are required in millions of biochemical reactions in human and animal bodies.  Here are just a few of the best studied examples:

一个强大而安全的甲基供体。TMG 很容易将三个甲基基团捐献给身体。甲基(CH3)是人体和动物体内数以百万计的生物化学反应所必需的。下面是一些最好的研究案例:

  • Lowering homocysteine. 降低同型半胱氨酸
  • Helping with liver detoxification. 帮助肝脏排毒
  • Alleviating depression. 缓解抑郁
  • Reducing the chances of diabetes. 减少患糖尿病的机会
  • Avoiding genetic problems. 避免遗传问题

TMG has an overall parasympathetic effect.  TMG seems to help restore balance to the autonomic nervous system, especially in those who are following a complete nutritional balancing program.  This may be one of its most important benefits.

TMG 有副交感神经的总体效应。似乎有助于恢复自主神经系统的平衡,特别是对于那些遵循完整的营养平衡计划的人。这可能是它最重要的好处之一。

TMG is good for those with an MTHFR defect
Anti-oxidant and anti-inflammatory effects.
Profound effects on the brain, digestion and other body systems.

TMG 对那些具有亚甲基四氢叶酸还原酶缺乏抗氧化和抗炎作用的人有好处。对大脑、消化系统和其他身体系统有深远的影响。

Elevated Homocysteine Levels increase risk factors for:

高同型半胱氨酸水平增加以下危险因素:

  • Cardiovascular disease 心血管疾病
  • Heart Attack, Stroke 心脏病发作,中风
  • Neural Tube Defects 神经管缺陷
  • Cancer 癌症
  • Liver Disease 肝病
  • Depression 抑郁症
  • Peripheral Neuropathy 周围神经病

Taken with permission from “Your Life Depends on it! Understanding Homocysteine Methylation and Your Health”, Paul Frankel, Ph.D., published with Specialty Laboratories, Santa Monica, CA.

获得“你的生命取决于它”的许可!理解同型半胱氨酸甲基化和你的健康” ,Paul Frankel 博士,发表于加利福尼亚州圣塔莫尼卡的专业实验室。

BIOLOGICAL BENEFITS OF TMG (Trimethylglycine)

TMG (甜菜碱)的生物效益

Betaine /TMG (not to be confused with Betaine HCL) works along with Vitamin B6, folic acid and Vitamin B12 to augment the formation of SAMe, an amino acid in the brain. Amino acids are proteins.

甜菜碱/TMG (不要与甜菜碱盐酸混淆)与维生素 B6、叶酸和维生素 B12一起作用,增加大脑中氨基酸的形成。氨基酸是蛋白质。

It helps with the Methylation process which is necessary for life

它有助于生命所必需的甲基化过程

TMG (Betaine Anhydrous) is a primary methyl donor with the following applications in human nutrition:

TMG (无水甜菜碱)是一种主要的甲基供体,在人类营养方面的应用如下:

  • By raising level of beneficial SAMe (S-Adenosyl-Methionine). 通过提高有益蛋白(s- 腺苷甲硫氨酸)的水平
  • Body building: In the animal husbandry field, TMG is used to decrease fat and increase meat yield. While human studies have just started, a 200 pound individual with 20% body fat can expect to lose as much as 5 pounds of fat and gain as much as 12 pounds of muscle. 健身: 在畜牧业领域,TMG 被用于减少脂肪和增加肉类产量。虽然人体研究才刚刚开始,一个体重200磅,体内脂肪含量为20% 的人可以减掉多达5磅的脂肪,增加多达12磅的肌肉
  • Cardiac protection: Conversion of homocysteine to Methionine. General Health Preventative: As part of a formula for maintaining good health or disease prevention. 心脏保护: 同型半胱氨酸转化为蛋氨酸。一般健康预防: 作为保持良好健康或预防疾病的配方的一部分
  • Glutathione Elevation: In several different studies, TMG has been shown to increase hepatic Glutathione, the body’s most important antioxidant. 谷胱甘肽升高: 在几个不同的研究中,TMG 已被证明能增加肝脏中谷胱甘肽,这是人体最重要的抗氧化剂
  • Homocysteine Lowering: Specific for that purpose. The supplement of choice for lowering homocystenuria 同型半胱氨酸降低: 专门用于此目的。补充降低同型半胱氨酸尿症的选择
  • Liver Disorders: As a part of liver-healing and protection formulas. Increases SAM levels in the liver, enables the liver to metabolize fat and protect against many challenges such as alcohol induced cirrhosis. TMG will also decrease bilirubin, alkaline phosphatase, and several other liver enzymes related to a large variety of liver disorders. Significant liver benefits have been shown in 20 studies. 肝脏疾病: 作为肝脏愈合和保护配方的一部分。增加 SAM 水平在肝脏,使肝脏代谢脂肪和保护对许多挑战,如酒精诱导肝硬化。TMG 还可以降低胆红素、碱性磷酸酶和其他一些与多种肝脏疾病有关的肝酶。20项研究已经显示了显著的肝脏益处
  • Longevity Formulations: As a part of a life extension formula. TMG has shown ability to protect interrogate of cellular DNA through methyl donation. 长寿配方: 作为延长寿命配方的一部分。TMG 已经显示出通过甲基捐赠来保护细胞 DNA 审问的能力
  • Methyl Donor Formulations: Along with B12, Folic acid, and Choline. 甲基供体配方: 除了 B12,叶酸和胆碱
  • : Due to its bi-polar nature, helps osmotic pressure in cells. For example it is used in salmon farming to protect fish against the problems of changing salt content. In humans, TMG maintains normal cellular electrolyte concentrations despite water and electrolyte losses during exercise. TMG also helps metabolize fats, which allows the body to burn fat rather than protein or muscle during exercise. The result is less cramping, increased endurance, and better utilization of fat stores : 由于它的双极性,有助于细胞中的渗透压。例如,它被用于鲑鱼养殖,以保护鱼类免受盐含量变化的影响。在人类,TMG 维持正常的细胞电解质浓度,尽管水和电解质损失在运动中。TMG 还有助于脂肪的新陈代谢,使身体燃烧脂肪,而不是蛋白质或肌肉在运动中。其结果是减少抽筋,增加耐力,和更好地利用脂肪储存

Here are some highlights from Nicolas  Rupcich’s  article on the potential exercise benefits of TMG consumption:

以下是 Nicolas Rupcich 关于 TMG 消费潜在运动益处的文章中的一些亮点:

The Power of Trimethylglycine (TMG) Supplementation
What benefits can be derived from supplementing with Trimethylglycine?

补充甜菜碱的力量补充甜菜碱有什么好处?

There have been several recent studies exploring the potential benefits of TMG supplementation, and most of them have yielded some impressive results. Nearly all studies examined a daily dosage of 2.5 grams of TMG. In many cases the dose was split with 1.25g twice per day.

最近有一些研究探索 TMG 补充剂的潜在益处,其中大多数已经产生了一些令人印象深刻的结果。几乎所有的研究都检查了每天2.5克 TMG 的剂量。在许多情况下,剂量分为1.25克每天两次。

While study designs varied between the clinicals, several benefits were perceived from supplementation with TMG at this level. Here’s a quick summary:

虽然研究设计不同之间的临床,几个好处被认为是补充 TMG 在这一水平。这里有一个简短的总结:

  • Weight-trained athletes taking 1.25g TMG twice daily increased muscle strength & power. 重量训练的运动员服用1.25克 TMG 每天两次增加肌肉力量和力量
  • TMG supplementation increased markers of protein synthesis vs. placebo. 补充 TMG 增加了蛋白质合成标志物与安慰剂
  • TMG enhanced endurance: allowing for more bench press reps, extended sprint capacity and more cycling power. 增强耐力: 允许更多的卧推代表,延长短跑能力和更多的自行车动力
  • TMG has also demonstrated positive influence on anabolic environment – increased GH and IGF-1 levels, yet decreased cortisol. TMG 也表现出对同化环境的积极影响——增加 GH 和 IGF-1水平,但降低皮质醇
  • Test subjects have increased muscle mass, arm size and decreased body fat. 实验对象的肌肉质量增加,手臂大小和身体脂肪减少
  • Many studies were 10-15 days in nature, demonstrating the potential for rapid benefits. 许多研究是10-15天的自然,证明了潜在的快速效益
  • One of the most recent studies in 2013 was 6 weeks long and showed that longer term TMG supplementation improved body composition, arm size, muscle power output and bench press work capacity. 2013年最新的研究之一是6周长,表明长期 TMG 补充改善身体成分,手臂大小,肌肉力量输出和卧推工作能力

So what’s net effect from all these results? Whether by means of improved cellular hydration, methyl donation or improved hormonal balance, trimethylglycine supplementation works. It improves muscle power output and endurance to enhance your workouts and maximize your time spent training. It is a vital supplement for those seeking optimal muscle power and performance.

那么,这些结果的净效应是什么呢?无论是通过改善细胞水合作用,甲基捐赠或改善荷尔蒙平衡,甜菜碱补充剂的工作。它可以提高肌肉的力量输出和耐力,增强你的锻炼,最大限度地利用你的训练时间。它是一个重要的补充,为那些寻求最佳的肌肉力量和表现。

Here is the article from Life-Enhancement Magazine:

以下是《生活增强》杂志的一篇文章:

Betaine Suppresses Inflammation During Aging: Possible Antiaging Effect
Betaine (also called trimethylglycine) is a nutritional component of many foods, including wheat, shellfish, spinach, and sugar beets.1 It is also available as an inexpensive dietary supplement. The function it serves in the plants that make it is to protect against osmotic stresses, such as drought, high salinity, or temperature stresses.

甜菜碱抑制衰老过程中的炎症: 可能的抗衰老作用甜菜碱是许多食物的营养成分,包括小麦、贝类、菠菜和甜菜。它也是一种廉价的甜菜碱膳食补充剂。它在植物中的作用是保护植物免受渗透胁迫,如干旱、高盐度或温度胁迫。

Earlier studies hypothesized that betaine contained in red wine and whole grain may play a role in the cardiovascular protective effect of those foods.1 It is also an important part of a major pathway for decreasing homocysteine in humans and other animals by contributing a methyl group for remethylating homocysteine to methionine.1

早期的研究假设,红酒和全谷物中所含的甜菜碱可能在这些食物的心血管保护作用中发挥作用

Betaine can be synthesized from choline, hence taking a betaine supplement is a way to spare choline for its other uses, such as to make acetylcholine and phosphatidylcholine.1 The authors of the paper (Ref 1) suggest that “… combined ingestion of folic acid and betaine may be the most effective method of lowering homocysteine.”

甜菜碱可以由胆碱合成,因此服用甜菜碱补充剂是一种减少胆碱用于其他用途的方法,例如制造乙酰胆碱和磷脂酰胆碱

They also note that some of the studies in which betaine supplementation lowered homocysteine concentrations and improved some clinical conditions (including heart disease and glucose tolerance in both diabetic and nondiabetic subjects) lasted for 13–16 years, and betaine dosage was typically 6 grams per day.
A new study2 now reports that betaine suppresses certain pro-inflammatory signaling factors during aging, including NF-kappaB. NF-kappaB controls the transcription of a number of inflammatory molecules, including tumor necrosis factor (TNF), interleukins (ILs), chemokines, adhesion molecules, and inducible enzymes, such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). All these inflammatory signaling agents are involved in conditions such as cancer, arthritis, and atherosclerosis.

他们还注意到,在一些研究中,添加甜菜碱降低同型半胱氨酸浓度,改善一些临床状况(包括糖尿病和非糖尿病患者的心脏病和葡萄糖耐量) ,这些研究持续了13-16年,甜菜碱剂量通常是每天6克。NF-kappaB 控制许多炎症分子的转录,包括肿瘤坏死因子-α 蛋白(TNF)、白细胞介素(ILs)、趋化因子、粘附分子和诱导酶,如环氧化酶2(COX-2)和诱导型一氧化氮合酶(iNOS)。所有这些炎症信号传导因子都与癌症、关节炎和动脉粥样硬化等疾病有关。

[They are also involved in certain conditions where inflammation is on net beneficial, especially fighting infections. Therefore, one should be cautious in using powerful drugs that block these signaling pathways—unless one has a serious medical condition that requires that degree of inhibition—that’s why you need a knowledgeable doctor familiar with both prescription drugs and nutrition.

在某些情况下,炎症反应也是有益的,特别是对抗感染。因此,在使用阻断这些信号通路的强效药物时应该谨慎小心ーー除非你患有严重的需要这种抑制程度的疾病ーー这就是为什么你需要一个既熟悉处方药又熟悉营养的博学的医生的原因。

Otherwise, mild suppression of inflammation via appropriate dietary supplements would be the way to go for healthy people or those with only a non-severe degree of inflammatory pathophysiology (such as mild arthritis).]

否则,通过适当的膳食补充剂轻度抑制炎症将是健康人或只有非严重程度的炎症病理生理(如轻度关节炎)的方法

This study is interesting because it looked at aging rats (Sprague-Dawley), which, like humans, have increasing levels of NF-kappaB in association with age, as well as with atherosclerosis, cancer, and other processes associated with oxidative stress and inflammation.2

这项研究之所以有趣是因为它观察了衰老的老鼠(Sprague-Dawley) ,这些老鼠和人类一样,随着年龄的增长,以及动脉粥样硬化、癌症和其他与氧化应激和炎症相关的过程,NF-kappaB 水平也会增加

“Recent reviews show that upregulated NF-kappaB activity seems to be a widespread biological phenomenon in aged animals and that NF-kappaB is a critical transcription factor involved in the pathogenesis of many disorders, including inflammatory diseases.”2
Betaine was added to regular rat chow at levels of 0.01%, 0.02%, or 0.04% and fed to 21-month-old rats for 10 days. On the basis that each rat ate on average 3 mg, 6 mg, or 12 mg of betaine, they ate 30, 60, or 120 mg/kg of body weight of betaine per day.

“最近的综述表明,上调 NF-kappaB 活性似乎是老年动物中普遍存在的生物学现象,NF-kappaB 是许多疾病包括炎症性疾病发病机制中的关键转录因子。”将甜菜碱分别添加到0.01% 、0.02% 、0.04% 的正常大鼠饲料中,饲喂21月龄大鼠10天。在每只大鼠平均摄入3毫克、6毫克或12毫克甜菜碱的基础上,它们每天摄入30、60或120毫克/千克体重的甜菜碱。

We suggest that, if you are not already taking betaine, you add it to your daily regimen. We both take it (Sandy takes 500 mg four times a day, and Durk takes 1 g four times a day).

我们建议,如果你还没有吃甜菜碱,你可以把它添加到你的日常饮食中。我们都服用(桑迪每天服用500毫克,杜克每天服用4次,每次1克)。

References

参考资料

  1. Craig. Betaine in human nutrition. 克雷格,人类营养中的甜菜碱Am J Clin Nutr 上午 j Clin Nutr 80:539-49 (2004). 80:539-49(2004)
  2. Eun Kyung Go et al. Betaine suppresses proinflammatory signaling during aging: the involvement of nuclear factor kappa B via nuclear factor-inducing kinase/IkappaB kinase and mitogen-activated protein kinases. 和其他人。甜菜碱抑制衰老过程中的促炎症信号: 核因子 -κb 通过核因子诱导激酶/ikappab 激酶和丝裂原活化蛋白激酶参与J Gerontol: Biol Sci 老年人: 生物科学 60A(10):1252-64 (2005). 60A (10) : 1252-64(2005)

Here is Nicholas Rupcich’s full article:
The Power of Trimethylglycine (TMG) Supplementation
So what is Trimethylglycine?

这里是 Nicholas Rupcich 的完整文章: 补充甜菜碱的力量那么什么是甜菜碱?

Trimethylglycine or TMG is also more commonly referred to as betaine (BEET-ah-een). For the chemists, as the name implies it is a trimethyl derivative of the common amino acid glycine. TMG is commonly found in our diet in beets (that’s where the name betaine came from), whole grains, spinach and shellfish.

甜菜碱或 TMG 也通常被称为甜菜碱(BEET-ah-een)。对于化学家,顾名思义,它是甘氨酸的三甲基衍生物。甜菜碱通常存在于我们的饮食中,甜菜碱(甜菜碱这个名字的由来) ,全谷物,菠菜和贝类。

TMG can also be made in the body naturally via oxidation of choline-containing compounds. One of its primary functions in the body is to act as an ‘osmolyte’ and increase water retention of cells. It migrates in and out of cells to preserve cellular hydration state. Like creatine, a higher cellular trimethylglycine concentration can help preserve cell structure and make the cell more resilient to stress.

TMG 也可以通过含胆碱化合物的氧化在体内自然产生。它在体内的主要功能之一是充当渗透剂,增加细胞的保水性。它在细胞内外迁移,以保持细胞的水合状态。像肌酸一样,更高的细胞甜菜碱浓度可以帮助保持细胞结构,使细胞更能适应压力。

Another important function of TMG is that it also acts as a methyl group donor in creatine synthesis as well as conversion of homocysteine to methionine. Some studies have shown that TMG supplementation may lower plasma homocysteine levels, this is important since elevated homocysteine levels can lead to blood vessel inflammation, making it a risk for heart disease.

TMG 的另一个重要功能是在合成肌酸以及将同型半胱氨酸转化为甲硫氨酸的过程中充当甲基供体。一些研究表明,TMG 补充剂可能降低血浆同型半胱氨酸水平,这是很重要的,因为高同型半胱氨酸水平可导致血管炎症,使其成为心脏病的风险。

Beyond its potential heart health benefits, TMG has also been the subject of a range of studies for its performance benefits. These human trials demonstrate a significant improvement in physical performance, especially in muscle strength, power and endurance.

除了其潜在的心脏健康的好处,TMG 也是一系列研究的主题,其性能的好处。这些人体试验表明,在身体表现,特别是在肌肉力量,力量和耐力显着改善。

What benefits can I get from supplementing with Trimethylglycine?

补充甜菜碱能给我带来什么好处?

There have been several recent studies exploring the potential benefits of TMG supplementation, and most of them have yielded some impressive results. Nearly all studies examined a daily dosage of 2.5 grams of TMG. In many cases the dose was split with 1.25g twice per day.

最近有一些研究探索 TMG 补充剂的潜在益处,其中大多数已经产生了一些令人印象深刻的结果。几乎所有的研究都检查了每天2.5克 TMG 的剂量。在许多情况下,剂量分为1.25克每天两次。

While study designs varied between the clinicals, several benefits were perceived from supplementation with TMG at this level. Here’s a quick summary:

虽然研究设计不同之间的临床,几个好处被认为是补充 TMG 在这一水平。这里有一个简短的总结:

  • Weight-trained athletes taking 1.25g TMG twice daily increased muscle strength & power. 重量训练的运动员服用1.25克 TMG 每天两次增加肌肉力量和力量
  • TMG supplementation increased markers of protein synthesis vs. placebo. 补充 TMG 增加了蛋白质合成标志物与安慰剂
  • TMG enhanced endurance: allowing for more bench press reps, extended sprint capacity and more cycling power. 增强耐力: 允许更多的卧推代表,延长短跑能力和更多的自行车动力
  • TMG has also demonstrated positive influence on anabolic environment – increased GH and IGF-1 levels, yet decreased cortisol. TMG 也表现出对同化环境的积极影响——增加 GH 和 IGF-1水平,但降低皮质醇
  • Test subjects have increased muscle mass, arm size and decreased body fat. 实验对象的肌肉质量增加,手臂大小和身体脂肪减少
  • Many studies were 10-15 days in nature, demonstrating the potential for rapid benefits. 许多研究是10-15天的自然,证明了潜在的快速效益
  • One of the most recent studies in 2013 was 6 weeks long and showed that longer term TMG supplementation improved body composition, arm size, muscle power output and bench press work capacity. 2013年最新的研究之一是6周长,表明长期 TMG 补充改善身体成分,手臂大小,肌肉力量输出和卧推工作能力

So what’s net effect from all these results? Whether by means of improved cellular hydration, methyl donation or improved hormonal balance, trimethylglycine supplementation works. It improves muscle power output and endurance to enhance your workouts and maximize your time spent training. It is a vital supplement for those seeking optimal muscle power and performance.

那么,这些结果的净效应是什么呢?无论是通过改善细胞水合作用,甲基捐赠或改善荷尔蒙平衡,甜菜碱补充剂的工作。它可以提高肌肉的力量输出和耐力,增强你的锻炼,最大限度地利用你的训练时间。它是一个重要的补充,为那些寻求最佳的肌肉力量和表现。

When is it optimal to take TMG? How much?

It’s quite evident from the consistency of the literature that the appropriate dosage of TMG is about 2.5 grams per day. Ideally it should be split in two doses 1.25g each; the first dose taken prior to training and the second either during or after your workout to replenish cellular stores.

何时服用 TMG 是最佳时机?多少钱?从文献的一致性可以很明显地看出,TMG 的适当剂量大约是每天2.5克。理想情况下,它应该分为两个剂量,每个1.25克; 第一个剂量采取之前的训练和第二个无论是在你的锻炼或之后补充细胞商店。

There are no known serious side effects of trimethlyglycine supplementation, and the longer term 6 week study supports that. It is important to note that you should look closely at the source of the TMG in products you may be considering and ensure that is listed as ‘Trimethylglycine’ or ‘Betaine Anhydrous’ and NOT ‘Betaine Hydrochloride (HCl)’ which is commonly used as fish food or for low stomach acid related digestion issues.

补充三甲基甘氨酸没有已知的严重副作用,长期6周的研究支持这一观点。值得注意的是,你应该密切关注你可能考虑的产品中的 TMG 的来源,并确保它被列为‘甜菜碱’或‘无水甜菜碱’ ,而不是‘盐酸甜菜碱’ ,后者通常用作鱼类食品或用于低胃酸相关的消化问题。

Nicholas Rupcich

尼古拉斯 · 鲁普西奇

Dr. Nicholas Rupcich holds a PhD in Biological Chemistry from McMaster University. He has over 10 years of experience in product development and formulation chemistry in the pharmaceutical and nutritional supplement industry, and has published numerous scientific paper and patents.

博士拥有麦马士达大学生物化学博士学位。他在制药和营养补充剂行业拥有10多年的产品开发和配方化学经验,并发表过多篇科学论文和多项专利。

Here is another article excerpt from Jim Stoppani, PhD on this topic:
Jim Stoppani’s Expert Guide to Betaine

By Jim Stoppani, Ph.D.

以下是 Jim Stoppani 博士关于这个话题的另一篇文章摘录: Jim Stoppani 的甜菜碱专家指南。

What are the Performance and Physique Applications?

什么是性能和形体应用?

In the last few years, clinical studies have looked at betaine supplementation in a number of modalities, from strength, to muscle growth, to endurance and sprinting performance. What do they all have in common? Betaine left the placebo in the dust.

在过去的几年中,临床研究已经观察了甜菜碱补充在一些方式,从力量,肌肉增长,耐力和短跑表现。它们有什么共同点?甜菜碱把安慰剂甩在了身后。

One of the first studies to look into betaine’s performance-supporting effects was done in my old lab at the University of Connecticut in 2010. The UCONN researchers found that weight-trained athletes taking 1.25 grams of betaine twice per day increased their muscle strength by 25 percent, and their muscle power by 20 percent.* They also determined that betaine significantly increased markers for muscle protein synthesis following a workout as compared to the placebo.*

2010年,我在康涅狄格大学以前的实验室里进行了第一批研究甜菜碱的表现支持作用的实验。康涅狄格大学的研究人员发现,经过体重训练的运动员每天服用两次1.25克甜菜碱,肌肉力量增加了25% ,肌肉力量增加了20% 。* 他们还发现,与安慰剂相比,甜菜碱显著增加了肌肉蛋白质合成的标记物。*

Since this initial study, other researchers have found that betaine supplementation helped lifters complete more total reps in bench press workouts, pedal with more power in cycling workouts, and sprint for almost 40 seconds longer than subjects drinking just water. Like the similar-sounding beta-alanine, it has also been suggested to significantly lower levels of lactate, which can delay muscular fatigue and allow athletes to train harder, for longer.*

自从这项最初的研究以来,其他研究人员已经发现补充甜菜碱可以帮助举重运动员在卧推练习中完成更多的重复练习,在自行车练习中用更多的力量踩踏板,并且比只喝水的实验对象多冲刺近40秒。像听起来相似的 β- 丙氨酸一样,它也被认为可以显著降低乳酸水平,乳酸水平可以延缓肌肉疲劳,让运动员更加努力地训练,训练时间更长。*

Researchers have found that betaine supplementation helped lifters complete more total reps in bench press workouts.

研究人员发现,在卧推练习中补充甜菜碱可以帮助举重运动员完成更多的总重复。

And then there’s the latest study on betaine, which comes from the College of Springfield in Massachusetts. Weight-trained males followed an undulating periodized weight-training program for six weeks.

还有最新的关于甜菜碱的研究,来自马萨诸塞州的斯普林菲尔德学院。负重训练的男性按照起伏周期的负重训练计划进行六个星期。

One group supplemented with 1.25 grams of betaine twice per day and one group supplemented with a placebo twice per day. They reported that the subjects supplementing with betaine increased muscle mass by 4 pounds and arm size by 10 percent, all while decreasing body fat by 7 pounds.* The placebo group experienced no increase in muscle mass or arm size and no loss of body fat.

一组每天两次添加1.25克甜菜碱,另一组每天两次添加安慰剂。他们报告说,服用甜菜碱的受试者肌肉质量增加了4磅,胳膊大小增加了10% ,同时身体脂肪减少了7磅。* 安慰剂组的肌肉质量和手臂大小没有增加,体脂肪也没有减少。

What’s to explain these incredible results? A recent study from UCONN indicated that these increases in muscle strength, power, and endurance may be due to betaine’s ability to increase levels of important anabolic substances while supporting a healthy balance of the catabolic hormone cortisol.*

如何解释这些令人难以置信的结果?康涅狄格大学最近的一项研究表明,这些肌肉力量、力量和耐力的增加可能是由于甜菜碱能够增加重要的合成代谢物质的水平,同时维持分解代谢激素皮质醇的健康平衡。*

Previous research also suggests that betaine supplementation increases nitric oxide and helps regulate cellular fluid volume, which could further promote muscle pump and overall muscle size.*

先前的研究也表明,甜菜碱补充增加一氧化氮和帮助调节细胞液体量,这可以进一步促进肌肉泵和整体肌肉大小。*

TMG is a compound which offers a spectrum of benefits ranging from mood modulation to cardiovascular health, exercise benefits and many more: it certainly warrants consideration as a core nutrient that most individuals could benefit from.

是一种复合物,它提供了从情绪调节到心血管健康的一系列益处,运动的益处和更多: 它当然值得考虑作为一个核心营养素,大多数人可以受益。

Biotics offers a Trimethylglycine Powder product, as well as a couple of other formulations which include TMG:

生物制品公司提供一种甜菜碱产品,以及其他一些配方,包括 TMG:

TMG Powder

TMG 爽身粉

Categories:

类别:

Amino-Acids, AntiInflammatory, Antioxidants, Anxiety-Support, Brain-Support, Cellular-Metabolism, Detoxification-Liver, Immune-Support, Liver-Detox, Metals-Detoxification, NPN, Neurological-Support, New-Products, Powders, Seasonal-Promotions

氨基酸,抗炎药,抗氧化剂,焦虑支持,脑支持,细胞代谢,解毒,肝脏,免疫支持,肝脏排毒,金属解毒,NPN,神经支持,新产品,粉末,季节促销

Quantity: 8 oz. (240 g)

收集数量: 8盎司(240克)

Description: TMG Powder (TRIMETHYLGLYCINE) Methyl Donor.

说明: TMG 粉末(甜菜碱)甲基供体。

http://drlwilson.com/ARTICLES/TRIMTHYLGLYCINE.htm

Indications:

适应症:

Use for Heavy Metal detoxification, especially Mercury and Copper, ADHD. neurological function and to reduce seizure activity. Helps to handle stress, improves oxygen utilization and enhances liver activity. Also used to enhance athletic performance. Also used to improve immune response, reduce tumours and to enhance anti-viral and anti-tumor defenses.

用于重金属解毒,特别是水银和铜,多动症。神经功能和减少癫痫活动。有助于处理压力,提高氧气利用率,增强肝脏活动。也用来提高运动员的表现。也用于提高免疫反应,减少肿瘤和增强抗病毒和抗肿瘤防御。

Benefits those with chronic fatigue, allergies, respiratory disorders, alcoholism and drug addiction. Also helps to reduce serum cholesterol and triglycerides and to normalize hypertension/glucose levels. It has been found beneficial to aid in sleep disorders. It is very important in the formation of collagen and is beneficial for connective tissue disorders of the ligaments, cartilage, arteries and veins. Helpful in reducing homocysteine levels.

对那些患有慢性疲劳、过敏、呼吸紊乱、酗酒和药物成瘾的人有益。还有助于降低血清胆固醇和甘油三酯,使高血压/血糖水平正常化。它被发现有助于治疗睡眠障碍。它对于胶原蛋白的形成非常重要,并且对于韧带、软骨、动脉和静脉的结缔组织有益。有助于降低同型半胱氨酸水平。

Use if Hair Tissue result indicates a \”sympathetic dominance\” profile as this profile may be consistent with a \”fight or flight\” scenario. Also used for those with an MTHFR genetic or methylation defects.

如果毛发组织结果表明“交感优势”的个人资料使用,因为这个个人资料可能是一致的“战斗或逃跑”的情况。也用于那些有 MTHFR 基因或甲基化缺陷的人。

Ingredients:

配料:

Trimethylglycine (Carboxmethyl) 3 grams per teaspoon

甜菜碱每茶匙3克

Suggestion:

建议:

Up to 1 teaspoon (3 grams) daily with food or as directed.

每日最多1茶匙(3克) ,随食或按指示服用。

TMG is a compound which offers a spectrum of benefits ranging from mood modulation to cardiovascular health, exercise benefits and many more: it certainly warrants consideration as a core nutrient that most individuals could benefit from.

是一种复合物,它提供了从情绪调节到心血管健康的一系列益处,运动的益处和更多: 它当然值得考虑作为一个核心营养素,大多数人可以受益。

Bio-GGG-B

生物 ggg-b

Categories: Adrenal-Support, AntiInflammatory, Cardiovascular-Support, Cellular-Metabolism, Digestion, Energy-Boost, Folic-Acid, Immune-Support, NPN, NeoNatal-Glandulars, Stamina, Vitamins

类别: 肾上腺支持,抗炎,心血管支持,细胞代谢,消化,能量提高,叶酸,免疫支持,NPN,新生儿腺,耐力,维生素

Quantity: 60 tablets

收集数量: 60粒

Description:

描述:

Phosphorylated B Vitamin Support. This product consists of 3 parts G fraction (riboflavin, niacin, folic acid, PABA and lipotrophic factors of choline, inositol & betaine and one part B fraction (thiamine, pantothenic acid and B12).

磷酸化 b 族维生素支持。该产品由3部分 g 组分(核黄素、烟酸、叶酸、 PABA 和胆碱、肌醇和甜菜碱的脂肪营养因子)和一部分 b 组分(硫胺素、泛酸和 B12)组成。

Indications: Use for inflammation, muscle spasms, and migraine headaches for increased riboflavin in hypertension, hyperlipidemia, night sweats, palm or sole of feet redness, edema, digestive difficulties, non-toxic goiter, inflammation, muscle spasms. Also indicated for those who “can’t get to sleep” at night”.

适应症: 用于炎症、肌肉痉挛、偏头痛、高血压、高脂血症、盗汗、手掌或足底发红、水肿、消化困难、无毒性甲状腺肿、炎症、肌肉痉挛。也适用于那些晚上“睡不着”的人。

Ingredients:

配料:

Vitamin C 60 mg
Thiamin (B1) as cocarboxylase chloride) 2 mg
Riboflavin (B2) as riboflavin-5-phosphate) 6 mg
Niacin (as niacinamide) 20 mg
B6 (as P-5-P) 12 mg
Folate 800 mcg
Vitamin B12 (as methylcobalamin)
Biotin 300 mcg
Panothenic Acid (as calcium pantothenate) 10 mg
Inositol
Neonatal liver (bovine)
Choline (as bitartrate)
PABA (para-aminobenzoic acid)
Trimethylglycine

Suggestion:
 2-4 tablets three times daily before meals or as directed.

维生素 c 60mgthiamin (B1)作为 co羧化酶氯化物2 mg Riboflavin (B2)作为核黄素-5-磷酸盐6 mg 烟酸(作为烟酰胺)20mg B6(作为 P-5-P)12mg 叶酸800mcg 维生素 B12(作为甲基钴胺)生物素300mcg panothacid (作为全烯酸钙)10mg 肌醇新生儿胆碱(作为苦参碱) PABA (对氨基苯甲酸)建议: 饭前或按指示每日2-4次。

Nutri-Clear NEW ADVANCED FORMULATION ACTIVATES AMPK

Categories:
 Alkalizing, Allergies, AntiInflammatory, Blood-Cleansing, Detoxification-Liver, Energy-Boost, Liver-Detox, Metals-Detoxification, NPN, Powders, Vegetarian

营养清除新型高级配方激活 AMPK 类: 碱化,过敏,抗炎,血液净化,解毒,肝脏,能量补充,肝脏排毒,金属解毒,NPN,粉末,素食

Quantity: 29.5 oz (836.3 grams) 1.84 lb

收集数量: 29.5盎司(836.3克)1.84磅

Description: Metabolic Clearing Formula Phase 1 and 2 Liver Detox: NEW ADVANCED FORMULATION!

说明: 新陈代谢清除配方1和2肝脏排毒: 新的先进配方!

Indications: Use for Metals detox.

用途: 用于金属排毒。

ACTIVATES AMPK. AMPK is a master control mechanism for cellular energy homeostasis. It determines body fat composition and has a significant impact on mitochondrial biogenesis, the diabesity spectrum and life span extension in mice models. To support hepatic detoxification and GI tract healing; use for digestive inflammation, leaky gut syndrome, ulcers, rheumatoid arthritis, and food sensitivities; use with Livotrit Plus™ for hepatic clearing. Detoxification is a complex process that demands nutrients over and above what are needed for normal daily functioning.

激活 AMPK。AMPK 是细胞能量稳态的主要控制机制。它决定了小鼠体内脂肪的组成,对线粒体的生物发生、糖耐量谱和寿命延长有重要影响。支持肝脏解毒和胃肠道愈合; 用于消化炎症、肠漏综合症、溃疡、类风湿性关节炎和食物过敏; 与 Livotrit PlusTM 一起用于肝脏清理。解毒是一个复杂的过程,需要的营养素超过正常日常功能所需。

Detoxification is an active process that involves at least two steps:
1) Oxidation: In a process that generates free radicals, an molecule of reactive oxygen is added to the toxin that is being processed. The purpose of this first step is to make the toxin ready for the second stage of the detoxification process. If nutrient supply is insufficient, then the first oxidative step may not proceed efficiently or the free radical damage from the biochemical reactions may increase oxidative stress and lead to tissue damage.

解毒是一个活跃的过程,至少包括两个步骤: 1)氧化: 在产生自由基的过程中,一个活性氧分子被添加到正在处理的毒素中。第一步的目的是为第二阶段的解毒过程做好准备。如果营养供应不足,那么第一个氧化步骤可能无法有效进行,或者生化反应引起的自由基损伤可能增加氧化应激,导致组织损伤。

2) Conjugation: The second phase of detoxification is the conjugation stage, wherein a molecule such as taurine, glycine, or glutathione is covalently bound to the toxin to increase its solubility in water. After the conjugation step, the toxin is ready to be excreted in the bile or urine. If nutrients are not sufficiently available for this second step, then the oxidized toxin cannot be excreted efficiently and may cause secondary damage by interacting with body tissues and DNA

2)结合: 第二阶段的解毒是结合阶段,其中分子如牛磺酸、甘氨酸或谷胱甘肽与毒素共价结合以增加其在水中的溶解度。在结合步骤后,毒素准备排泄在胆汁或尿液。如果没有足够的营养素来进行这第二步,那么氧化毒素就不能有效排出,并可能通过与身体组织和 DNA 相互作用造成二次损害

Ingredients:

配料:

Calories 120
Calories from Fat 20%
Total Fat 2g 3%
Saturated Fat 1.5g 8%
Cholesterol 0mg 0%
Sodium 300mg 13%
Potassium 460mg 13%
Total Carbohydrate 7g 2%
Dietary Fiber 1g 4%
Sugars 6g
Protein 17g 34%
Serving Size: 2 level scoops (approx. 33.5 g)
Not a significant source of iron.
Percent Daily Values based on a 2,000 calorie diet. Your Daily Values may be higher or lower depending on your calorie needs.

热量120卡路里来自脂肪20% 总脂肪2克3% 饱和脂肪1.5克8% 胆固醇0毫克0% 钠300毫克13% 钾460毫克13% 总碳水化合物7克2% 膳食纤维1克4% 糖6克蛋白质17克34% 食用分量: 2勺(约33.5克)不是铁的重要来源。基于2000卡路里饮食的每日摄入量百分比。你的每日摄入量可能会根据你的卡路里需求而有所变化。

Daily Value Amount Per Serving

每一食用分量的每日价值

Ingredients: Pea protein isolate, organic evaporated cane juice, potassium citrate, calcium magnesium citrate, medium chain triglycerides, natural flavors, magnesium citrate malate, L-Glutamine, trimethylglycine, calcium ascorbate, stevia leaf extract, zinc picolinate, N-Acetyl-L-Cysteine, natural mixed carotenoids, d-alpha-tocopheryl acetate, quercetin, natural mixed tocopherols, manganese gluconate, molybdenum aspartate, pyridoxal-5-phosphate, L-Glutathione, L-Threonine, L-Lysine HCl, niacinamide, copper gluconate, calcium pantothenate, selenium aspartate, cocarboxylase chloride, riboflavin-5-phosphate, chromium picolinate, potassium iodide, vitamin D3, biotin, 5-methyltetrahydrofolic acid glucosamine salt, calcium folinate, and methylcobalamin.

成份: 豌豆分离蛋白、有机蒸发甘蔗汁、柠檬酸钾、柠檬酸钙镁、中链甘油三酯、天然香料、苹果酸镁、 l- 谷氨酰胺、甜菜碱、抗坏血酸钙、甜菊叶萃取物、吡啶酸锌、 n- 乙酰 -l- 半胱氨酸,天然混合类胡萝卜素、 d- α- 生育酚乙酸酯、槲皮素、天然混合生育酚、葡萄糖酸锰、天门冬氨酸钼、吡哆醛 -5- 磷酸酯、 l- 谷胱甘肽、 l- 苏氨酸、 l- 赖氨酸盐,尼克酰胺、葡萄糖酸铜、泛酸钙、门冬氨酸硒、羧化酶氯化物、核黄素 -5- 磷酸盐、吡啶羧酸铬、碘化钾、维生素 D3、生物素、5- 甲基四氢叶酸氨基葡萄糖盐、亚叶酸钙和甲胺钴。

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

* 食品和药物管理局尚未对此声明进行评估。本产品不用于诊断、治疗、治疗或预防任何疾病。

ALSO CONTAINS (per serving):

同样包含(每份) :

**Trimethylglycine 500 mg
**L-Glutathione 10 mg
** N-Acetyl-L-Cysteine 50 mg
**L-Glutamine 500 mg
**Quercetin 25 mg

甜菜碱500毫克 l- 谷胱甘肽10毫克 n- 乙酰 -l- 半胱氨酸50毫克 l- 谷氨酰胺500毫克槲皮素25毫克

Suggestion: Blend, shake, or briskly stir 2 level scoops (44 grams) of NutriClear into 8 oz. of chilled water or the beverage of your choice.

建议: 混合,摇动,或轻快搅拌2水平勺(44克)裸核李尔到8盎司。冷却水或饮料。

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